https://ameblo.jp/rem0705/ 　Estinto ja アメンバー限定公開記事です。 https://ameblo.jp/rem0705/amemberentry-11480617882.html Thu, 28 Feb 2013 21:22:44 +0900 アメンバー限定公開記事です。 https://ameblo.jp/rem0705/amemberentry-11480614100.html Thu, 28 Feb 2013 21:18:14 +0900 アメンバー限定公開記事です。 https://ameblo.jp/rem0705/amemberentry-11480609997.html Thu, 28 Feb 2013 21:16:42 +0900 アメンバー限定公開記事です。 https://ameblo.jp/rem0705/amemberentry-11480605415.html Thu, 28 Feb 2013 21:10:24 +0900 Like Growth Factor Signaling, Confers Specific Protection Against
Stress-Induced Aggregation. Reduced signaling of the insulin/insulin-
like growth factor (IGF) pathway protects C. elegans from
several environmental stressors, including hyperosmotic stress
(25, 27, 33). Protection against hyperosmotic stress depends on
the activity of several protein chaperones that are up-regulated
by the FOXO transcription factor daf-16 (33). Such protection
could occur either by preventing the formation of osmotically
induced protein aggregates or by mitigating the physiological
effects of such aggregates. To distinguish between these possibilities,
we crossed the daf-2(e1370) mutant, which causes constitutive
FOXO signaling and protects against hyperosmotic
stress, into the threshold-length polyQ lines. We confirmed that
in these polyQ backgrounds, daf-2(e1370) still activates DAF-16/
FOXO signaling (i.e., formation of dauer larvae at the restrictive
temperature) and provides protection against hyperosmotic
stress [increased 24-h survival on 500 mM NaCl (33)]. The daf-2
(e1370) mutation had no effect on osmotically induced polyQ
aggregate formation in muscle (Fig. S7), and caused only
a modest delay in the kinetics of osmotically induced aggregate
formation in the intestine (Fig. 5 A and B). By contrast, daf-2
mutants exhibit a substantial reduction in the formation of
intestinal age-induced polyQ aggregates (Fig. S6). Therefore,
a reduction in IGF signaling strongly attenuates the formation
of aging-induced Q44-YFP aggregates but has substantially
weaker effects on the formation of osmotically induced
Q44-YFP aggregates.
Another signaling pathway that protects C. elegans from
hyperosmotic stress is the osmotic stress resistance (Osr) pathway
(17, 34–36). Previously, we and others showed that Osr
mutants, such as osm-7 and osm-8, constitutively activate an
osmosensitive gene expression program and have high levels of
the organic osmolyte glycerol (17, 28, 35). However, these
mutants do not exhibit transcriptional patterns characteristic of
the response to other stressors such as heat shock or oxidative
stress (17), and in the case of the osm-8 mutant are resistant to
lethal levels of hyperosmotic stress but not heat shock or oxidative
stress (34). We crossed the Osr mutants osm-7(n1515) and
osm-8(n1518) into the vha-6p::Q44-YFP background and found
that osmotically induced aggregation was strongly attenuated
(Fig. 5 C and D). The protective effect of the Osr mutants is not
limited to the intestine, because the Osr mutants also protect
muscle cells against osmotically induced aggregation (Fig. S7).
We also found that the Osr mutants osm-7 and osm-8 provided
significant protection against aging-induced polyQ aggregation in
the intestine, although such protection was significantly weaker
than that provided by daf-2(e1370), which does not contain elevated
levels of glycerol (33) (Fig. S6). Together, these data show
that genetic and physiological activation of the osmotic stressresponse
pathway, but not the IGF-signaling pathway, attenuates
stress-induced polyQ aggregation in multiple tissues. Furthermore,
the Osr pathway provides weak but significant protection
against aging-induced polyQ aggregation.
]]> https://ameblo.jp/rem0705/entry-11480603586.html Thu, 28 Feb 2013 21:08:52 +0900 アメンバー限定公開記事です。 https://ameblo.jp/rem0705/amemberentry-11480602236.html Thu, 28 Feb 2013 21:07:38 +0900 アメンバー限定公開記事です。 https://ameblo.jp/rem0705/amemberentry-11480601240.html Thu, 28 Feb 2013 21:02:57 +0900 宇宙での金曜日の午後
方向性も失い　男女　犬
子供たち　馬　詩
ダニ　ポットやパン
プールに酒
思想を生み出し　盗用し
悟りの境地が生まれる
私がこの世を作った
すべて分かってるさ
ろくでもない世界を
作り上げた
本物だと信じてしまった
でもきっと大丈夫さ
少年少女をなだめられるよ
そして光り輝く永遠の世は
語り継がれる
ペンキ塗りの話から始まる―
こんな広大な話は
聞いたことあるか？
小さな巣を掘っているアリ
細菌にやられている腎臓
水星をむしばむ中型生物
社会を形成する微生物の微生物
永遠に続く空間の原子つまり
空想の宇宙に向かっていく
終わりもなく
バンクが母親を岩に放り投げ
人々は彼の小屋に訪ねに向かう
"他にどんな惑星がある？"
"何のことだ？"
この世の音が酔っ払ってる
マカディオラ家を通り過ぎる
猫たちがバーでフェンスで
月光の下で泣き声を上げる
ルシアンのテーマ　広大な視野
純粋さと傷
無限の無形の
金属系の黄金の灰
啓発された脳の中で
揺れて群がる
耳の奥まで鳴り響く
音のない音
それでも我々は聞くことを拒み
"何？　誰？"と聞き返す
"何に？　君に？"
遠くにはダイアモンドの船
ミルタウンとヘロイン
永遠の銀色の年と調和する
ごく普通のほうきで
群れとなる
夜には根っこの霊から
四角い光を照らす
コヨーテは聞いていないが
存在しない悪魔から守る
時間をつぶしていたら
はるかなる距離の最後を超える
金曜の午後に
それらの音は始まった
仕事を終え
帰宅してビールを飲む
そして子供の目に触れる





]]> https://ameblo.jp/rem0705/entry-11479398928.html Wed, 27 Feb 2013 01:43:17 +0900 アメンバー限定公開記事です。 https://ameblo.jp/rem0705/amemberentry-11478405123.html Mon, 25 Feb 2013 20:05:37 +0900 アメンバー限定公開記事です。 https://ameblo.jp/rem0705/amemberentry-11478404661.html Mon, 25 Feb 2013 20:04:27 +0900